Yeah, the only one I found was me killing the app I think:

3/17/12 7:14:09.149 PM com.apple.launchd.peruser.501: ([0x0-0x21021].com.aptonic.Dropzone[200]) Exited: Killed: 9

Dropzone 2.1 becomes unresponsive on Lion.

Both the Menu Bar and Right hand activation became unresponsive.

Had to Force Quit App from Activity Monitor and restart it from the Applications Folder, and now is working again.

But for how long?